Characterization of a cis-acting regulatory element in the protein-coding region of human dihydrofolate reductase mRNA
نویسندگان
چکیده
منابع مشابه
Characterization of a cis-acting regulatory element in the protein-coding region of human dihydrofolate reductase mRNA.
Previous studies have shown that human DHFR (dihydrofolate reductase), in addition to its critical role in DNA biosynthesis, functions as an RNA-binding protein. The interaction between DHFR and its own mRNA results in translational repression. In this study, we characterized the cis-acting elements on human DHFR mRNA that are required for the DHFR mRNA-DHFR protein interaction. Using a series ...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 2004
ISSN: 0264-6021,1470-8728
DOI: 10.1042/bj20031396